Table I.
Comparison of variables among the OC, CKD and HC groups.
| Variable | OC (n=31) | CKD (n=38) | HC (n=36) |
|---|---|---|---|
| S-HE4 (pmol/l) | 439 (43–4927)a | 670.1 (41–3212)a | 45.65 (28–76) |
| U-HE4 (pmol/l) | 28,560 (6752–98740)a,b | 5790 (1,621–37,024) | 6,573 (3,220–12,542) |
| R-HE4 | 71.091 (14.7–309.7)a,b | 8.7 (1.7–149.5)a | 134.4 (71.9–281.3) |
| Creatinine (µmol/l) | 56.7 (37.9–95.3)b | 279.9 (69.8–980.2)a | 48.2 (34.2–76.3) |
| eGFR (ml/min/1.73m2) | 102.9 (52.2–127.3)b | 18.2 (3.0–78.3)a | 116.8 (70.1–138.3) |
| Serum cystatin C (mg/l) | 0.71 (0.5–1.31)b | 2.91 (1.15–7.66)a | 0.66 (0.38–0.94) |
a
P<0.05 vs. HC
b
P<0.05 vs. CKD. OC, ovarian cancer; CKD, chronic kidney disease; HC, healthy control; HE4, human epididymis protein 4; S-, serum; U-, urine; R-HE4, ratio of urinary-to-serum HE4 level; eGFR, estimated glomerular filtration rate.