Table II.

Diagnostic performance of HE4 in differentiating patients with ovarian cancer from healthy control subjects.

Variable	Serum HE4	Urine HE4	R-HE4
Area under the curve	0.955	0.959	0.815
P-value	<0.001	<0.001	<0.001
95% CI	0.907–1.004	0.915–1.003	0.705–0.926
Cut-off value	88.65	14116	96.15
Sensitivity (%)	87.1	83.9	71.0
Specificity (%)	100.0	100.0	88.9
Youden's index (%)	87.1	83.9	59.9

HE4, human epididymis protein 4; R-HE4, ratio of urinary-to-serum HE4 level; CI, confidence interval.