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. 2017 Jun 30;10:206. doi: 10.3389/fnmol.2017.00206

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Copyright © 2017 Raj, Yin, Breur, Doorduin, Holtman, Olah, Mantingh-Otter, Van Dam, De Deyn, den Dunnen, Eggen, Amor and Boddeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Age-associated immunoreactivity increases in CD68 and HLA-DR. (A) Immunostaining for CD68 and HLA-DR in young, middle aged, and aged human brain. The regions are cortex and cerebellum. The boundary between white and gray matter regions is drawn in green. (B) Quantification of immunostaining for CD68 and HLA-DR shows clear differences in white matter compared to corresponding gray matter within the same brain region. Changes in white matter start in middle aged samples (Young, n = 3; Middle aged, n = 6; Aged, n = 6). Scale bar: (A) = 200 μm, insert = 25 μm. Mann–Whitney’s test ^∗P < 0.05, ^∗∗P < 0.005, ^∗∗∗P < 0.0005. Error bars indicate standard deviation (SD).