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. 2017 Jun 30;10:206. doi: 10.3389/fnmol.2017.00206

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Copyright © 2017 Raj, Yin, Breur, Doorduin, Holtman, Olah, Mantingh-Otter, Van Dam, De Deyn, den Dunnen, Eggen, Amor and Boddeke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PET studies using [¹¹C]-PK11195 to localize age-associated microglial activation in white matter. Axial image of the human brain showing white matter [¹¹C]-PK11195 average uptake in (A) young and (B) middle aged healthy volunteers (n = 7); (C) Positive correlation between [¹¹C]-PK11195 binding potential (BP_P) in the total corpus callosum and age of subjects.