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. 2017 Jun 30;10:206. doi: 10.3389/fnmol.2017.00206

FIGURE 6.

FIGURE 6

White matter immunoreactivity in IBA1, HLA-DR and CD68 increases in early-onset AD, but not in late-onset AD. (A) Transentorhinal cortex (EC) and frontal cortex (FC) sections of early-onset AD (Braak stage V-VI, n = 5), late-onset AD (Braak stage V-VI, n = 4) and their age-matched controls (Braak stage 0-I; Young controls n = 13; Old controls n = 3) are immunostained for IBA1, HLA-DR, and CD68. (B) Quantification of positive pixels of IBA1, HLA-DR, and CD68 staining shows that the expression of IBA1, HLA-DR, and CD68 increases in early-onset AD, compared to age-matched controls. There is no significant differences of IBA1, HLA-DR, or CD68 expression between the late-onset AD and age-matched controls. Scale bar: (A) = 40 μm. Mann–Whitney test, ∗P < 0.05, ∗∗P < 0.01, Error bars indicate standard error.