Table II.
I/D polymorphism genotyping and allelic frequencies between the study groups.
| Parameter | Control group (n=48) | T2DM (n=70) | HTN (n=48) | HTN + T2DM group (n=54) |
|---|---|---|---|---|
| Genotype, n (%) | ||||
| II | 28 (58.3) | 6 (8.6) | 2 (4.2) | 3 (5.6) |
| ID | 18 (37.5) | 30 (42.8) | 24 (50.0) | 30 (55.5) |
| DD | 2 (4.2) | 34 (48.6) | 22 (45.8) | 21 (38.9) |
| χ2 test sig. (2-sided) | P<0.0001 between all groups | |||
| Allele, n (%) | ||||
| I | 74 (77.1) | 42 (30) | 28 (29.2) | 36 (33.3) |
| D | 22 (22.9) | 98 (70) | 68 (70.8) | 72 (66.7) |
| Total | 96 | 140 | 96 | 108 |
| Fisher's exact test sig. (2-sided) | P<0.0001a | P<0.0001a | P<0.0001a | |
| Odds ratio | 7.85 | 8.17 | 6.73 | |
| (95% confidence interval) | (3.90–15.78) | (3.73–17.88) | (2.90–15.59) |
a
P<0.05 vs. Control group using χ2 and/or Fisher's exact tests. T2DM, type 2 diabetes mellitus; HTN, hypertension.