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. 2017 Jun 30;8:440. doi: 10.3389/fphar.2017.00440

FIGURE 1.

FIGURE 1

Effect s of P. daemia on PTZ challenge outcome. (A) Effects of P. daemia extract on the latency to myoclonic jerks, clonic seizures and generalized tonic–clonic seizures induced by pentylenetetrazol challenge in pilocarpine-injected mice. (B) Effect of P. daemia extract on the duration of myoclonic jerks, clonic seizures and generalized tonic–clonic seizures in the same animals. (C) Effects of P. daemia on the seizures score. Data are mean ± SEM, N = 7 per group. Newman Keul’s multiple comparisons post hoc test, with Mann–Whitney U test correction: (i) vs. control animals (DW + DW group) receiving only distilled water: ∗p < 0.05, ∗∗p < 0.01; (ii) ∗∗∗p < 0.001 vs. disease control animals (DW + PILO group) receiving distilled water and pilocarpine: ap < 0.05, bp < 0.01. CS, clonic seizures; DW, distilled water; MJ, myoclonic jerks; GTCS, generalized tonic–clonic seizures; PD, Pergularia daemia; PILO, pilocarpine; VIC, vitamin C; SVA, sodium valproate.