FIG. 4.

Necropsy observations for effects of parasite infection and side effects from febrifugine and halofuginone treatments in test mice. (A) Mice treated with toxic doses of halofuginone developed diarrhea, as indicated by the arrows; (B) different lethal effects caused by malarial parasites (left) and toxic dose of febrifugine (right); (C) gastrointestinal tract injury in a mouse due to the oral administration of 5 mg of halofuginone per kg (left) compared with that in a mouse due to subcutaneous treatment (right).