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. 2017 Feb 11;20(7):562–574. doi: 10.1093/ijnp/pyx010

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© The Author 2017. Published by Oxford University Press on behalf of CINP.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Figure 5. — Effects of l-aminocyclopropanecarboxylic acid (ACPC)/7-chloro-4-hydroxy-3-(3-phenoxy)phenyl-2(1H)-quinolone (L-701,324) on morphine-induced cognitive and behavioral changes in D3^-/- mice. (a) D3^-/- mice were administered ACPC (200 mg/kg), L-701,324 (3 mg/kg), or Veh (1% Tween-80) i.p. in combination with 10 mg/kg morphine or saline for 7 days. *P < .05, ***P < .0001, vs Veh controls within the saline- or morphine-treated groups. (b) The fold changes in the numbers of premature and perseverative responses in wild-type (WT) and D3^-/- mice. In each genotype, the data from the Veh+Saline group were set as 1, and the data from the other treatment groups are expressed as the relative fold change vs the Veh+Saline group. *P < .05, ***P < .0001, comparison between the 2 indicated groups.