Table 1.
5-CSRTT Baseline Performance in the WT, D1-/-, and D3-/- Mice
| WT | D1 -/- | D3 -/- | ANOVA | |
|---|---|---|---|---|
| Accuracy (%) | 90.58±3.39 | 10.51±2.43*** | 45.11±16.43**, ## | F2, 45 = 32.56, P < .0001 |
| Omission (%) | 18.08±2.79 | 81.24±7.76*** | 16.03±3.43### | F2, 45 = 51.7, P < .0001 |
| Premature response | 7.0±1.89 | 0.21±0.08 | 14.57±4.22*, # | F2, 45 = 5.77, P = .0138 |
| Correct response lat. (s) | 0.68±0.06 | 17.05±4.38*** | 0.28±0.16## | F2, 45 = 34.45, P < .0001 |
| Perseverative response | 7.1±1.79 | 0.16±0.1*** | 0.77±0.24** | F2, 45 = 12.78, P = .0006 |
| Timeout response | 22±6.89 | 2.1±1.26* | 17.5±6.95 | F2, 45 = 3.884, P = .0412 |
| Feeder lat. (s) | 1.18±0.16 | 13.18±1.4** | 1.11±0.21### | F2, 45 = 70.52, P < .0001 |
| Trials completed | 91.67±4.02 | 5.72±1.28*** | 67.19±3.96***, ### | F2, 45 = 271.5, P < .0001 |
Data are mean±SEM. One-way ANOVA followed by Sidak’s posthoc test was used to analyze difference between genotypes. *P < .05, **P < .01, ***P < .0001, compared with WT mice. #P < .05, ##P < .01, ###P < .0001, compared between D1-/- and D3-/- mice.