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Effects of simocyclinones D4 and D8 on gyrase ATPase activity. (Top panel) The N-terminal ATPase domain of GyrB (GyrB43; 20 μM) was incubated with increasing concentrations of novobiocin and simocyclinones D4 and D8, and the rates of hydrolysis were determined and plotted as the residual ATPase activity against the drug concentration. (Bottom panel) Gyrase (A2B2; 70 nM) was incubated with increasing concentrations of simocyclinone D8 in the presence of linear pBR322 DNA (2.8 nM).
