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Effect of simocyclinone D8 on gyrase relaxation. Gyrase (60 nM) and supercoiled pBR322 DNA (6 nM) were incubated with increasing concentrations of novobiocin (Novo), simocyclinone D8, and ciprofloxacin (CFX) for 1 h at 37°C. NC, nicked circle; R, relaxed; SC, supercoiled.
