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Binding of simocyclinone D8 to GyrA59 by isothermal titration calorimetry. The integrated data, after correction for the heat of ligand dilution as a function of the molar ratio, is presented as kilojoules per mole of injectant versus the molar ratio of drug/protein. The solid line shows the best fit obtained by least-squares regression by use of a one-site model. This analysis gave an approximate stoichiometry of 1:1.
