Table 2.

Adjusted estimates for mean hepatic copper tissue concentrations.

Comparison	Parameter Estimate	95%lower	95%upper	p-value
NAFLD vs. non-NAFLD	−5.61	−9.45	−1.77	0.005
NAFL vs. NASH	2.67	−0.01	5.34	0.054
Steatosis Grade	−4.10	−5.65	−2.54	<0.001
Lobular Inflammation	0.17	−1.86	2.20	0.870
NAS	−1.38	−2.47	−0.29	0.015
Portal Inflammation	1.59	−0.26	3.43	0.100
Fibrosis	−1.41	−4.32	1.49	0.468
Ballooning	0.04	−1.91	1.99	0.968

Analysis included subjects with tissue copper concentrations within normal range, 10– ≤ 35 μg/g. Adjusted for age, BMI z-score, GGT, ALT, total bilirubin

NAFLD, non-alcoholic fatty liver disease; NASH, non-alcoholic steatohepatitis; NAS, NAFLD Activity Score.