Table 1.
Patient characteristics and annual atrophy changes in the corpus callosum and cerebellum
| Total (n = 48) |
SCA (n = 21) |
MSA-C (n = 17) |
CCA (n = 10) |
p value | |
|---|---|---|---|---|---|
| Age at onset (years) | 52.6 ± 12.5 | 46.2 ± 13.1* | 57.5 ± 10.0 | 57.6 ± 9.2 | 0.005 |
| Age at study entry (years) | 60.5 ± 11.3 | 56.6 ± 12.5* | 61.4 ± 9.4 | 67.1 ± 9.0 | 0.046 |
| Male (%) | 50% | 62% | 47% | 30% | 0.241 |
| Body height (cm) | 159.3 ± 9.0 | 160.3 ± 9.2 | 163.0 ± 8.0 | 154.7 ± 8.2 | 0.124 |
| AP diameter of the cranium (mm) | 181.4 ± 8.6 | 180.6 ± 8.4 | 185.0 ± 6.3 | 177.2 ± 10.7 | 0.061 |
| Follow-up period (years) | 3.1 ± 1.6 | 3.1 ± 1.7 | 2.7 ± 1.1 | 3.6 ± 1.8 | 0.522 |
| Follow-up period (min-max) | (1.25–7.58) | (1.50–7.58) | (1.25–4.67) | (1.25–6.00) | |
| Number of follow-up studies, median (min-max) | 3 (2–6) | 3 (2–6) | 3 (2–6) | 4 (2–6) | 0.083 |
| Interval between onset and the first evaluation (years) | 8.0 ± 6.4 | 10.4 ± 7.3 | 4.0 ± 3.3* | 9.4 ± 5.3 | 0.004 |
| Interval between the first and last evaluation (years) | 2.6 ± 1.5 | 2.6 ± 1.6 | 2.2 ± 1.3 | 3.1 ± 1.6 | 0.308 |
| ICARS score at the first visit | 35.5 ± 16.5 | 36.7 ± 12.9 | 35.8 ± 23.0 | 33.2 ± 14.0 | 0.871 |
| Initial corpus callosum area (mm2) | 598.2 ± 79.2 | 575.2 ± 80.6 | 657.9 ± 84.9 | 587.0 ± 47.8 | 0.042 |
| Initial corpus callosum area index (Adx) | 3.38 ± 0.45 | 3.33 ± 0.50 | 3.46 ± 0.47 | 3.32 ± 0.26 | 0.622 |
| Annual atrophy area in Adx | −0.11 ± 0.08 | −0.09 ± 0.07 | −0.15 ± 0.10 | −0.08 ± 0.05 | 0.026 |
| Initial cerebellar volume (cm3) | 84.9 ± 13.7 | 88.1 ± 12.7 | 85.5 ± 8.8 | 78.4 ± 17.9 | 0.276 |
| Initial cerebellar volume index (Vdx) | 0.47 ± 0.09 | 0.48 ± 0.08 | 0.45 ± 0.09 | 0.47 ± 0.11 | 0.725 |
| Annual atrophy volume in Vdx | −0.04 ± 0.02 | −0.02 ± 0.02 | −0.04 ± 0.02† | −0.01 ± 0.03 | 0.019 |
| Annual increase in ICARS score | 4.4 ± 4.5 | 3.5 ± 2.9 | 9.8 ± 6.1* | 2.9 ± 2.8 | 0.021 |
*p < 0.05 vs. the other two subtypes (post-hoc analysis), † p < 0.05 vs. CCA (post-hoc analysis)