. 2017 Jun 29;10:39. doi: 10.1186/s13048-017-0338-z

Table 6.

The diagnostic criteria of the ROC curve for MMP-7, TIMP-1, HE4 and CA125 in epithelial ovarian cancer patients

Epithelial ovarian cancer	The ROC criteria	MMP-7	TIMP-1	HE4	CA 125
Stage I	AUC	0.7801^a	0.5769	0.8343^a	0.8324^a
	SE	0.0693	0.0718	0.0582	0.0471
	95% C.I.	0.644–0.916	0.436–0.718	0.720–0.948	0.740–0.925
	pAUC = 0.5	0.0001	0.2840	<0.001	<0.001
Stage II	AUC	0.7938^a	0.6109	0.8462^a	0.8825^a
	SE	0.0639	0.0772	0.0479	0.0397
	95% C.I.	0.669–0.919	0.460–0.762	0.752–0.940	0.805–0.960
	pAUC = 0.5	<0.001	0.1506	<0.001	<0.001
Stage III	AUC	0.8905^a	0.7740^a	0.9521^a	0.9331^a
	SE	0.0485	0.0643	0.0288	0.0327
	95% C.I.	0.796–0.986	0.648–0.900	0.896–1.008	0.869–0.997
	pAUC = 0.5	<0.001	<0.001	<0.001	<0.001
Stage IV	AUC	0.8679^a	0.7314^a	0.8994^a	0.9458^a
	SE	0.0624	0.0778	0.0511	0.0252
	95% C.I.	0.746–0.990	0.579–0.884	0.799–1.000	0.896–0.995
	pAUC = 0.5	<0.001	0.0029	<0.001	<0.001
Total group	AUC	0.8335^a	0.6372^a	0.8836^a	0.8988^a
	SE	0.330	0.0425	0.0263	0.0235
	95% C.I.	0.769–0.898	0.554–0.721	0.832–0.935	0.853–0.945
	pAUC = 0.5	<0.001	0.0013	<0.001	<0.001

C.I. – confidence intervals of AUC

^aStatistically significant when comparing tested parameters AUC’s with 0.5 AUC

Bold data are statistically significant when p < 0.05