Markers of liver injury. A, Alanine aminotransferase; B, Aspartate aminotransferase; C, Gene markers of cell matrix and fibrosis; D, Translation of genes involved in matrix formation and fibrosis in young and old mice in the absence or presence trehalose in the drinking water (+ trehalose: 2% trehalose for 4 weeks). Srebp1c, a transcription factor involved in lipogenesis, was used as a negative control in monosome and polysome assays. Values are means ± SDEV for n=7–8 per group. * P<0.05 vs. other groups.