Markers of inflammatory signaling. A, Plasma IL6 and IL18; B, Phosphorylation of JNK in the liver; C, Inflammasome gene expression; D, Caspase-1 activity in young and old mice in the absence or presence trehalose in the drinking water (+ trehalose: 2% trehalose for 4 weeks). Values are means ± SDEV for n=7–8 per group. Representative gels provided above relevant figures (Y = young, Y+T = young + trehalose, O = old, O+T = old + trehalose). * P<0.05 vs. other groups.