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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Neuropharmacology. 2017 Mar 18;118:124–136. doi: 10.1016/j.neuropharm.2017.03.018

Figure 2. Injection of Ch-ABC within the LHAad blocks the acquisition of cocaine- but not sucrose-induced CPP.

Figure 2

Data represent time spent on cocaine- or sucrose-paired side (mean ± SEM) recorded during initial preference (IP) and test day following injections of vehicle and Ch-ABC (0.054 U/side). (A) Timeline of the CPP experiment. (B) Acquisition of cocaine-induced CPP was observed following vehicle pretreatment but not following injections of Ch-ABC into the LHAad (P < 0.05). (C) Injections sites in cocaine CPP trained animals that received vehicle (black circles) and Ch-ABC (gray circles) microinjections within the LHAad. (D) Sucrose-induced CPP was observed following injection of both vehicle and Ch-ABC into the LHAad. (E) Injection sites in sucrose CPP trained animals that received vehicle (black circles) and Ch-ABC (gray circles) microinjections within the LHAad. (F) Ch-ABC injections into brain regions adjacent, outside, but not within the LHAad failed to block the acquisition of cocaine-induced CPP. (G) Injection sites in rats tested for cocaine CPP that received vehicle (black circles) and Ch-ABC (gray circles) microinjections.