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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Immunol Rev. 2017 Jul;278(1):192–206. doi: 10.1111/imr.12554

Figure 1. Ontogeny of ILC2s.

Figure 1

Common lymphoid progenitors (CMPs) differentiated to early innate lymphoid cell progenitors (EILP) which express NFIL3, TCF-1 and TOX. EILPs have the potential to differentiate to conventional NK cells or further develop to common progenitor to all helper-like ILCs (CHILP). CHILPs express the key transcriptional regulator Id2 and can generate lymphoid tissue inducers (LTi) and ILC1, ILC2 and ILC3. By Expression of PLZF CHIPs differentiate to innate lymphoid cell progenitor (ILCP) which can develop to all three subsets of innate lymphoid cells. ILCPs further differentiate to ILC2 progenitors (ILC2P) by expressing ETS1, Gfi1and increasing the expression of Gata-3. ILC2Ps can only generate ILC2s which express Bcl11b, RORα and high levels of Gata-3.