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. Author manuscript; available in PMC: 2018 May 22.
Published in final edited form as: Dev Cell. 2017 May 22;41(4):366–381.e4. doi: 10.1016/j.devcel.2017.04.014

Figure 7. Exogenous integrin β8 rescues vascular defects in ric8a mutants.

Figure 7

See also Figure S7.

(A–D) Exogenous GFP has no obvious effects on vessel morphology in wildtype striata (A) and does not rescue defects in ric8a mutants (B). Exogenous integrin β8 also has no effects on wildtype striata (C), but rescues mutant defects (D). Note absence of glomeruloid structures in (D) in comparison to (B) (arrows).

(E–H) Exogenous GFP has no obvious effects on apoptosis (arrows) in wildtype striata (E) and does not rescue apoptosis in ric8a mutants (F). Exogenous integrin β8 also has no effects on wildtype striata (G), but suppresses apoptosis in mutants (H).

(I) Quantification of glomeruloid areas shows near complete suppression by β8 expression in ric8a mutants. **, p < 0.01; n = 12.

(J) Quantification of vessel density shows restoration to a level indistinguishable from wildtype by β8 expression in ric8a mutants. **, p < 0.01; n = 10.

(K) Quantification of apoptotic cell number shows significant suppression by β8 expression in ric8a mutants. *, p < 0.05; n = 12.

Scale bars: 200μm in A–D and 100μm in E–H.