FIGURE 3.

¹⁸F-PARPi in brain tumor models (6,12). (A) Maximum-intensity projections from orthotopic U251 tumor–bearing mice. (B) ¹⁸F-PARPi biodistribution 2 h after intravenous injection in U251 tumor–bearing athymic nude mice (subcutaneous xenograft). (C) ¹⁸F-PARPi uptake in genetically engineered diffuse intrinsic pontine glioma mouse model, compared with MRI and histology. (D) Imaging of tumor growth progression in genetically engineered diffuse intrinsic pontine glioma mouse model. White arrows indicate tumor, and orange arrows accumulation of cerebrospinal fluid. H&E = hematoxylin and eosin.