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. Author manuscript; available in PMC: 2018 Jul 1.
Published in final edited form as: Br J Haematol. 2017 Jun 4;178(1):119–129. doi: 10.1111/bjh.14751

Figure 1. Effect of platelets on clot stiffness.

Figure 1

Rheological properties of evolving clots were investigated using dynamic mechanical analysis at 37°C for 30 min. (A) Representative traces of storage modulus, G′ (clot stiffness) for clots formed from plasma, plasma with platelets (300 ×109 platelets /l) and plasma with lyophilized platelets (300 ×109 platelets /l); (B) Clot stiffness increases by 6-fold with physiological concentration of live platelets in plasma (n=3; *, P<0.05). (C) Platelets failed to form stable clots on blocking glycoprotein IIb/IIIa receptor (Eptifibatide) or actin polymerization (Cytochalasin B). [n=3; ns, not significant (P >0.05); *, P < 0.05; **, P<0.01; ***, P<0.001]. Lyo, lyophilized platelets; PPP, platelet poor plasma; PRP, platelet rich plasma.