Table 4.

External Beam Radiation therapy Only +/−NADT distribution of participant responses to EPIC Hormone/Vitality HRQOL items at baseline, 6, 12, and 24 months.

	NADT			No NADT			P value*
How big a problem during the last 4 weeks, if any, has each of the following been for you?	Moderate problem +Big problem	No Problem + Very small problem + Small problem	n	Moderate problem +Big problem	No Problem + Very small problem + Small problem	n
Hot flashes							0.0924
Baseline:	1.2%	98.8%	84	1.0%	99.0%	202
6 months:	33.3%	66.7%	78	2.2%	97.8 %	182
12 months:	20.8%	79.2%	77	0.5%	99.5%	181
24 months:	7.3%	92.8 %	69	2.4%	97.6%	166
Breast tenderness/enlargement[1]							0.8611
Baseline:	0%	100%	85	1.5%	98.5%	201
6 months:	2.6%	97.4%	78	1.7%	98.3%	181
12 months:	1.3%	98.7%	77	1.7%	98.3%	181
24 months:	2.9%	97.1%	69	1.2%	98.8%	167
Feeling depressed							0.8733
Baseline:	3.5%	96.5%	85	6.9%	93.1%	202
6 months:	3.9%	96.2%	78	6.1%	93.9%	181
12 months:	6.5%	93.5%	77	8.3%	91.7%	181
24 months:	5.8%	94.2%	69	4.8%	95.2%	167
Lack of energy							0.0003
Baseline:	5.9%	94.1%	85	13.9%	86.1%	202
6 months:	35.9%	64.1%	78	14.9%	85.1%	181
12 months:	20.8%	79.2%	77	17.2%	82.8%	180
24 months:	15.9%	84.1%	69	16.8%	83.2%	167
Change in body weight							0.1251
Baseline:	3.6%	96.4%	84	4.5%	95.5%	202
6 months:	12.8%	87.2%	78	3.9%	96.1%	181
12 months:	14.3%	85.7%	77	3.9%	96.1%	179
24 months:	10.1%	89.9%	69	4.8%	95.2%	167

P value reflects a test of the interaction term between group and the time points in linear generalized estimating equations (GEE).

^[1]Cochran-Mantel-Haenszel test