TABLE 2.
Perioperative alteration patterns of blood TNF-α, IL-6, and IL-8 production after LPS stimulationa
| Cytokine responses | No. of patients with:
|
|
|---|---|---|
| Increase in TNF-α production | Decrease in TNF-α production | |
| Increases in IL-6 and IL-8 production | 10 | 2 |
| Increase in IL-6 production and decrease in IL-8 production | 1 | 4 |
| Decrease in IL-6 production and increase in IL-8 production | 4 | 5 |
| Decreases in IL-6 and IL-8 production | 4 | 18 |
a
A postoperative increase or decrease in LPS-stimulated production of one of the three cytokines was associated with a corresponding uniform alteration for the other two cytokines (TNF-α versus IL-6, P = 0.013, Fisher; TNF-α versus IL-8, P = 0.001, Fisher; IL-6 versus IL-8, P = 0.007, Fisher). A total of 48 patients were studied.