TABLE 3.
Distribution of TNF genotypes in patients with a perioperative increase or decrease in TNF-α production after LPS stimulation
| Genotype | No. of patients with:
|
Pa | |
|---|---|---|---|
| Increase in TNF-α production | Decrease in TNF-α production | ||
| TNF-α −308 | |||
| A/A | 2 | 0 | |
| A/G | 9 | 5 | |
| G/G | 8 | 24 | 0.009 |
| TNF-β NcoI | |||
| TNFB1/TNFB1 | 5 | 2 | |
| TNFB1/TNFB2 | 6 | 14 | |
| TNFB2/TNFB2 | 8 | 13 | 0.153 |
| TNF-α −308-TNF-β NcoI | |||
| A/A-TNFB1/TNFB1 | 2 | 0 | |
| A/G-TNFB1/TNFB1 | 3 | 1 | |
| A/G-TNFB1/TNFB2 | 4 | 4 | |
| A/G-TNFB2/TNFB2 | 2 | 0 | |
| G/G-TNFB1/TNFB1 | 0 | 1 | |
| G/G-TNFB1/TNFB2 | 1 | 10 | |
| G/G-TNFB2/TNFB2 | 7 | 13 | 0.034 |
a
The P value determined by χ2 is the level of statistical significance for differences in genotype distribution between patients with increases and those with decreases in TNF-α production.