TABLE 4.
TNF-α −308-TNF-β NcoI haplotypes and perioperative changes in LPS-stimulated blood TNF-α production
| Haplotype | No. of patients with increase/ no. of patients with decrease, in TNF-α-producing capacitya
|
rs (P)c | Pd | |||
|---|---|---|---|---|---|---|
| 2b | 1 | 0.5 | 0 | |||
| A*TNFB1 | 2/0 | 3/1 | 5/4 | 9/24 | 0.399 (0.005) | 0.042 |
| A*TNFB2 | 0/0 | 1/0 | 5/4 | 25/13 | 0.222 (0.129) | 0.229 |
| G*TNFB1 | 0/1 | 4/11 | 5/4 | 10/13 | −0.151 (0.304) | 0.422 |
| G*TNFB2 | 5/2 | 5/4 | 2/10 | 7/13 | −0.230 (0.116) | 0.081 |
a
Haplotypes of heterozygotes were scored as 0.5 for each haplotype.
b
Number of haplotypes.
c
rs, correlation between the numbers of the patients with an increase or decrease in TNF-α secretion.
d
Determined by χ2.