Table 6.
Body weight, organ weight and serum liver enzyme profile of normal and 5 g/kg body weight of Xeniji treated mice for 30 days of subchronic toxicity study
| Normal | Xeniji 0.1 | Xeniji 1.0 | Xeniji 2.0 | |
|---|---|---|---|---|
| Day 0 BW (g) | 20.42 ± 0.125 | 18.96 ± 0.271 | 19.96 ± 1.297 | 19.67 ± 1.145 |
| Day 28 BW (g) | 24.52 ± 1.370 | 22.91 ± 1.023 | 23.93 ± 1.837 | 23.52 ± 1.116 |
| BW gain (g) | 4.10 ± 1.245 | 3.96 ± 0.752 | 3.97 ± 0.541 | 3.86 ± 0.029 |
| Liver/BW ratio | 0.04 ± 0.005 | 0.04 ± 0.001 | 0.04 ± 0.004 | 0.04 ± 0.009 |
| Kidney/BW ratio | 0.01 ± 0.001 | 0.01 ± 0.001 | 0.01 ± 0.001 | 0.01 ± 0.001 |
| Spleen/BW ratio | 0.003 ± 0.000 | 0.003 ± 0.000 | 0.003 ± 0.000 | 0.003 ± 0.000 |
| Glucose (mmol/L) | 5.50 ± 0.99 | 5.40 ± 0.07 | 5.13 ± 0.76 | 5.00 ± 0.41 |
| ALT (U/L) | 53.68 ± 3.32 | 44.62 ± 1.83*# | 44.33 ± 4.76* | 43.55 ± 2.21*# |
| ALP (U/L) | 72.33 ± 3.84 | 72.67 ± 3.37 | 79.67 ± 4.80 | 78.83 ± 1.89 |
| AST (U/L) | 103.97 ± 4.15 | 108.32 ± 2.10 | 108.04 ± 2.93 | 107.21 ± 5.83 |
| Creatinine (μmol/L) | 43.50 ± 0.40 | 42.00 ± 0.40 | 43.00 ± 0.95 | 42.50 ± 0.21 |
*and #indicates a significant difference compared with the normal control group at p < 0.05 and p < 0.001