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. 2017 Jun 30;19:150. doi: 10.1186/s13075-017-1336-7

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 4 — Top scoring networks derived from the proteins with different abundance (≥1.2-FC) at Stage II compared to Stage I of the autologous chondrocyte implantation (ACI) procedure in those who responded well clinically (responders; a) and those who did not respond clinically (non-responders; b). Red nodes represent greater protein abundance at Stage II of ACI; green nodes represent lower protein abundance at Stage II of ACI; and white nodes represent inferred proteins which are not differentially expressed between Stage I and Stage II (based on label-free quantification proteomic analysis). The key to the features within the network is shown. APOB Apolipoprotein B-100, CD3 T-cell surface glycoprotein CD3, Ck2 Casein kinase 2, COL1A1 Collagen alpha-1(I) chain, COL1A2 Collagen alpha-2(II) chain, C4 Complement C4, DYNC1H1 Cytoplasmic dynein 1 heavy chain 1, ERK Mitogen-activated protein kinase 3, ERP29 Endoplasmic reticulum resident protein 29, F7 Coagulation factor VII, FCN3 Ficolin-3, GABRAPL2 Gamma-aminobutyric acid receptor-associated protein-like 2, GBA Glucosylceramidase, GMFB Glia maturation factor beta, GPLD1 Phosphatidylinositol-glycan-specific phospholipase D, HINT1 Histidine triad nucleotide-binding protein 1, HDL-cholesterol High density lipoprotein-cholesterol, HMGB2 High mobility group protein B2, HSP76 Heat shock protein 76, IGFBP6 Insulin-like growth factor binding protein 6, Jnk Mitogen-activated protein kinase, LCAT Phosphatidylcholine-sterol acyltransferase, LDL Low-density lipoprotein receptor, LTF Lactotransferrin, MASP1 Mannan-binding lectin serine protease 1, MASP2 Mannan-binding lectin serine protease 2, MYH10 Myosin-10, MYLK Myosin light chain kinase, smooth muscle, NFkB complex nuclear factor kappa-light-chain-enhancer of activated B cells complex, PAM Peptidyl-glycine alpha-amidating monooxygenase, PDCD6IP Programmed cell death 6-interacting protein, PF4 Platelet factor 4, PI3K complex Phosphoinositide-3 kinase complex, PLG Plasminogen, POSTN periositin, PSMA7 Proteasome subunit alpha type-7, P38 MAPK P38 mitogen-activated protein-kinases, Rock Rho-associated protein kinase 1, RPL22 60S ribosomal protein L22, Rxr retinoic X receptor, STX7 Syntaxin-7, Tgf beta Transforming growth factor beta, Vegf Vascular endothelial growth factor