FIG. 8.

Proposed role(s) of Chlamydomonas Trxh1 in the response to DNA-damaging agents. A function of Trxh1 in DNA damage avoidance (detoxification of genotoxic agents) and the transcriptional activation of stress response genes is inferred from the well-documented role of cytosolic thioredoxins in other eukaryotes. Our results suggest a specialized function of Chlamydomonas Trxh1 in the repair of alkylation-induced DNA damage (see the text for details). DSBR, DNA DSB repair; HR, homologous recombination; MMR, mismatch repair; TLS, translesion DNA synthesis.