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. Author manuscript; available in PMC: 2017 Jun 30.
Published in final edited form as: J Med Chem. 2017 Apr 4;60(7):2879–2889. doi: 10.1021/acs.jmedchem.6b01815

Figure 4.

Figure 4

Cysteines at different locations; sulfur atom in yellow, cysteine in green; and ligand in blue. (a) Cysteine at P-loop (pdb id 4r6v). (b) Cysteine at roof of the binding pocket (pdb id 4riy). (c) Cysteines at location Hinge-1 of the hinge region (representative pdb id 3m2w). (d) Cysteines at location Hinge-2 of the hinge region (representative pdb id 2ywp). (e) Cysteines at location Hinge-3 of the hinge region (representative pdb id 3lco). (f) Cysteines at location Catalytic-2 of the catalytic loop (representative pdb id 1t46). (g) Cysteines at location Catalytic-9 of the catalytic loop (representative pdb id 4a0j). (h) Cysteine at location DFG-4 close to the DFG peptide (representative pdb id 3wf7).