Table 2. The antiviral IC₅₀ against Herpes simplex virus-1 (HSV-1) and acyclovir-resistant Herpes simplex virus (HSV-ACR) of PRE, punicalagin, ZnSO₄ and ellagic acid in comparison to aciclovir (n = 3 ± SD).

Note: IC₅₀ concentration of PRE is in units of mass mL^-1 rather than μM as it is a complex mixture of compounds.

Challenge	MW	Virus	IC50 (μg mL-1)	IC50 (μM)
PRE + ZnSO4	N/A	HSV-1	0.550 ± 0.062	N/A
PRE	N/A	HSV-1	0.560 ± 0.039	N/A
		HSV-ACR	0.016 ± 0.009	N/A
Punicalagin	1084.7	HSV-1	≥108.47	≥100
		HSV-ACR	≥108.47	≥100
Ellagic acid	302.2	HSV-1	≥30.22	≥100
		HSV-ACR	≥30.22	≥100
ZnSO4	161.47	HSV-1	≥16.15	≥100
		HSV-ACR	≥16.15	≥100
Aciclovir	225.21	HSV-1	0.182	0.81 ± 0.03
		HSV-ACR	≥22.52	≥100