FIGURE 2. Entorhinal Cortex Thickness by Age and Apolipoprotein Eε4 Status^a.

^aThe left panel plots baseline entorhinal cortex thickness against baseline age for 157 patients with Alzheimer’s disease enrolled in the Alzheimer’s Disease Neuroimaging Initiative. Red dots indicate patients with ε4– status (N=50), and blue dots indicate patients with ε4+ status (N=107). The heavy red line is fitted from a linear model for ε4– patients, and the heavy blue line is fitted from the same model for ε4+ patients. The right panel plots longitudinal entorhinal cortex thickness for the same patients, using data from baseline and all follow-up assessments. The heavy red line is fitted from a linear mixed-effects model for ε4– patients, and the heavy blue line is fitted from the same model for ε4+ subjects. Entorhinal cortex thickness is standardized to have a mean of zero and a standard deviation of 1 at baseline.