FIGURE 3. Longitudinal Entorhinal Cortex Thickness, by Age and Apolipoprotein E ε4 (APOE-ε4) Status, With Cohort Effects^a.

^aLongitudinal entorhinal cortex thickness measures for patients with Alzheimer’s disease with ε4– (N=50) and ε4+ (N=107) status. Heavy lines and line segments indicate model fitted from linear mixed-effects model including age cohort, change in age from baseline, and APOE-ε4 status. Line segments extending from the longer lines indicate departures of within-subject slopes (change in age from baseline) from age cohort slopes, for seven age cohorts (55, 60, 65, 70, 75, 80, and 85 years of age at baseline).