Fig 6. Cartoon model of Cosmc structure.

(A) A representation of Cosmc with an N-terminal domain (dark blue) that is responsible for interacting with the client (red peptide) and a smaller, C-terminal domain (light blue) that mediates oligomerization and metal binding (Zn²⁺). A putative tetramer is shown for illustration purposes only, however our data is consistent with heterogeneous oligomeric states. (B) An atomic model of Cosmc’s glycosyltransferase homology region based on Mfng (PDB ID 2J0B) using SWISS-MODEL. The glycosyltransferase homology region within Cosmc is restricted to the N-terminal domain.