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. 2017 Jun 30;12(6):e0180455. doi: 10.1371/journal.pone.0180455

Fig 5. Superoxide scavenging exacerbates arterial remodeling in rats with severe PAH.

Fig 5

A) Representative immunofluorescence images of lung sections from normoxic (top row) and hypoxic (bottom row) rats treated with SU5416 and/or TEMPOL. Smooth muscle α-actin (green), Von Willebrand factor (red), and sytox (blue). B) Percent muscularization calculated as percent thresholded smooth muscle α-actin area divided by total arterial wall area according to arterial diameter: 10–25 μm (left), 25–50 μm (middle), and 50–100 μm (right). Values are means ± SE; n = 4 animals/group. *P ≤ 0.05 vs. normoxic group; # P < 0.05 vs. corresponding SU5416-vehicle group; τ p < 0.05 vs. TEMPOL-vehicle group; analyzed by multiple two-way ANOVA and individual groups compared with the Student-Newman-Keuls test.