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. 2017 Jun 30;12(6):e0180455. doi: 10.1371/journal.pone.0180455

Fig 6. Superoxide scavenging exacerbates adventitial remodeling in rats with severe PAH.

Fig 6

Representative immunofluorescence images of lung sections from rats treated with normoxic vehicle (A), hypoxic vehicle (B), hypoxia/SU5416 (C), or hypoxia/SU5416/TEMPOL (D). Sections were incubated with anti-smooth muscle α-actin (SMA, green) and either vimentin (red, left) or HSP-47 (red, right). Summary data showing average percent area of positive immunofluorescence from 10 random 20x images per lung section for E) SMA, F) vimentin, and G) HSP-47. Values are means ± SE; n = 4 animals/group. *P ≤ 0.05 vs. normoxic group; # P < 0.05 vs. corresponding SU5416-vehicle group; τ p < 0.05 vs. TEMPOL-vehicle group; analyzed by multiple two-way ANOVA and individual groups compared with the Student-Newman-Keuls test.