Fig 9. ET-1-induced VSM Ca²⁺ sensitization and vasoconstriction are augmented in small pulmonary arteries from animals treated with SU5614.

(A) Basal tone (baseline diameter as a % of Ca²⁺-free diameter) in non-permeabilized, endothelium-disrupted, pressurized small pulmonary arteries. (B) vasoconstriction (% baseline diameter) to endothelin-1 (ET-1; 10⁻¹⁰ to 10⁻⁷ M) in Ca²⁺-permeabilized, endothelium-disrupted, pressurized small pulmonary arteries from rats treated with vehicle or SU5416 and exposed to normoxia or hypoxia. Values are means ± SE; n = 5–6 animals/group. *P ≤ 0.05 vs. normoxic group; #P <0.05 vs. corresponding vehicle treatment; analyzed by two-way ANOVA and individual groups compared with the Student-Newman-Keuls test.