Fig 11. Enhanced basal tone and ET-1-induced pulmonary VSM Ca2+ sensitization following hypoxia/SU5416 is mediated by Rho kinase (ROK).
(A) HA-1077-mediated change in vessel diameter (% baseline diameter) in non-permeabilized, endothelium-disrupted, pressurized small pulmonary arteries. (B) Vasoconstriction (% baseline diameter) to endothelin-1 (ET-1; 10−10 to 10−7 M) in the presence of HA-1077 (10 μM) in Ca2+-permeabilized, endothelium-disrupted, pressurized small pulmonary arteries from normoxic and hypoxic rats treated with vehicle or SU5416. (C) Effect of HA-1077 on ET-1 mediated vasoconstriction in each group compared to vehicle-treated arteries (from Fig 9). Values are means ± SE; n = 4–5 animals/group; * p < 0.05 vs. vehicle-treated arteries; analyzed by two-way ANOVA and individual groups compared with the Student-Newman-Keuls test.