Table 1. Body weight, heart weight ratios, hematocrit, and heart rate from rats treated with TEMPOL, SU5416 or vehicle and exposed to normoxia or hypoxia.
| Final BW (g) | RV/BW (mg/g) | LV/BW (mg/g) | RV/Total (mg/mg) | Hematocrit (%) | Heart Rate (beats/min) | |
|---|---|---|---|---|---|---|
| Normoxia Vehicle | ||||||
| Vehicle | 337 ± 4 (24) | 0.61 ± 0.01 (19) | 2.23 ± 0.04 (19) | 0.21 ± 0.003 (21) | 45.6 ± 0.4 (17) | 315 ± 12 (5) |
| TEMPOL | 331 ± 4 (11) | 0.58 ± 0.02 (5) | 2.06 ± 0.05 (5) τ | 0.22 ± 0.01 (5) | 44.5 ± 1.1 (6) | 322 ± 14 (5) |
| Normoxia SU5416 | ||||||
| Vehicle | 330 ± 5 (14) | 0.75 ± 0.06 (13) # | 2.36 ± 0.04 (13) # | 0.24 ± 0.01 (13) # | 44.3 ± 0.5 (7) | 287 ± 16 (5) |
| TEMPOL | 338 ± 6 (11) | 0.67 ± 0.03 (5) | 2.04 ± 0.05 (5) τ | 0.25 ± 0.004 (5) # | 43.8 ± 1.3 (6) | 301 ± 24 (5) |
| Hypoxia Vehicle | ||||||
| Vehicle | 284 ± 3 (27) * | 1.11 ± 0.02 (23) * | 2.19 ± 0.03 (23) | 0.34 ± 0.005 (23) * | 68.4 ± 0.6 (24) * | 312 ± 13 (5) |
| TEMPOL | 297 ± 6 (11) *τ | 0.99 0.06 (5) * | 2.04 ± 0.05 (5) | 0.32 ± 0.02 (5) * | 69.0 ± 0.6 (6) * | 291 ± 9 (5) |
| Hypoxia SU5416 | ||||||
| Vehicle | 270 ± 4 (30) *# | 1.53 ± 0.04 (25) * # | 2.30 ± 0.05 (25) * # | 0.40 ± 0.008 (26) * # | 63.8 ± 0.8 (27) * # | 298 ± 15 (5) |
| TEMPOL | 263 ± 3 (11) *# | 1.58 ± 0.02 (5) * # | 2.42 ± 0.06 (5) * # | 0.40 ± 0.003 (5) * # | 62.5 ± 1.2 (6) * # | 297 ± 33 (5) |
Values are means ± SE; n = animals/group (indicated in parentheses).
*P < 0.05 vs. the corresponding normoxia group
# P < 0.05 vs. the corresponding SU5416-vehicle group
τ P < 0.05 vs. the corresponding TEMPOL-vehicle group; analyzed with two- or three-way ANOVA and individual groups compared with the Student-Newman-Keuls test. BW, body weight; RV, right ventricle; LV, left ventricle.