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. 2017 Jun 30;12(6):e0180535. doi: 10.1371/journal.pone.0180535

Fig 1. DNMT1 was target gene of miR-148a.

Fig 1

(A) miR-148a is highly complementary to pig DNMT1 3'UTR. This potential miR-148a target site is conserved in human, cows, mice and pigs. (B) Schema contains WT and Mut 3-′UTRs of DNMT1, indicating the interaction sites between miR-148a and 3-′UTR of DNMT1. (C) Schema of miR-148a precursor sequence in pEZX-MR03. (D) Luciferase activities were measured in 293T cells co-transfected with the pEZX-DNMT1 (wild type or mutant) and pEZX-miR-148a or pEZX-miR-control. The data were reported as mean ± S.D. for three independent experiments (p < 0.05).