TABLE 3.

Conservation of key residues in cyclophilins^a

Protein	Length	Position				% Conserved	TargetP prediction
		55	60	121	126
PPIA_HUMAN	165	R	F	W	H	100	— (2)
CYN16 C_240021 modified	190	*	*	Q	*	75	— (3)
CYN17 C_20323	180	*	G	F	R	25	— (2)
CYN18-1 C_20046 modified	162	*	*	H	Y	50	— (3)
CYN18-2 C_1010007	157	*	*	*	*	100	— (2)
CYN19-1 C_250142	>338	*	*	*	*	100	— (2)
CYN19-2 C_3230001	172	*	*	*	*	100	— (2)
CYN19-3 C_790042	201	*	*	*	*	100	— (3)
CYN20-1 C_290072	222	*	*	*	*	100	S (4): 36
CYN20-2 C_70215	243	*	*	*	*	100	C (4): 39
CYN20-3 C_740054	200	*	*	*	*	100	M (2): 30
CYN20-4 C_990048	229	X	X	—	—	<50	— (4)
CYN20-5 C_660007	340	*	*	H	*	75	M (4): 48
CYN22 C_910055	187	*	*	*	*	100	— (3)
CYN23 C_2260002	235	*	*	H	Y	50	S (2): 19
CYN26-2 C_460089 modified	310	G	Y	D	N	0	C (4): 40
CYN28 C_1220009 modified	350	*	E	R	N	25	C (3): 45
CYN37 C_90033	288	A	V	A	F	0	— (3)
CYN38 C_30248 modified	413	*	*	N	F	50	M (4): 27
CYN40 C_180001	369	*	*	H	*	75	— (4)
CYN51 C_200140 modified	465	*	*	H	Y	50	M (4): 9
CYN52 C_1560006 modified	482	*	*	H	*	75	S (1): 28
CYN53 C_1560025 modified	583	*	*	H	Y	50	M (3): 12
CYN57 C_1280001	585	*	Y	*	N	50	S (3): 24
CYN59 C_480065 modified	486	N	*	S	*	50	— (3)
CYN65 C_800078 modified	586	*	*	H	*	100	— (4)
CYN71 C_320104/C_19080001	?	*	*	—	—	<50	?
AtCYP18-1 At1g01940	160	*	*	H	Y	50	— (4)
AtCYP18-2 At2g36130	164	*	*	S	*	100	— (3)
AtCYP18-3 At4G38740	172	*	*	*	*	100	— (2)
AtCYP18-4 At4G34870	172	*	*	*	*	100	— (3)
AtCYP19-1 At2G16600	173	*	*	*	*	100	— (2)
AtCYP19-2 At2g21130	174	*	*	*	*	100	— (2)
AtCYP19-3 At3g56070	176	*	*	*	*	100	— (5)
AtCYP19-4 At2G29960	201	*	*	*	*	100	S (1): 23
AtCYP20-1 At5G58710	204	*	*	*	*	100	S (1): 23
AtCYP20-2 At5g13120	259	*	*	*	*	100	C (1): 70
AtCYP20-3 At3g62030	260	*	*	*	*	100	C (1): 77
AtCYP21-1 At4g34960	224	*	*	*	*	100	S (2): 27
AtCYP21-2 At3g55920	228	*	*	*	*	100	S (1): 31
AtCYP21-3 At2G47320	230	*	*	D	L	50	M (4): 47
AtCYP21-4 At3G66654	236	*	Y	D	L	25	C (4): 61
AtCYP22 At2g38730	199	*	*	*	*	100	— (5)
AtCYP23 At1g26940	226	*	*	H	Y	50	S (1): 22
AtCYP26-1 At3g22920	232	H	L	Q	*	25	— (3)
AtCYP26-2 At1g74070	314	K	Y	E	V	0	C (1): 45
AtCYP28 At5g35100	289	K	Q	Q	N	0	C (2): 70
AtCYP37 At3g15520	464	T	A	S	F	0	C (2): 65
AtCYP38 At3g01480	437	*	*	N	Y	50	C (1): 36
AtCYP40 At2g15790	361	*	*	H	*	75	— (2)
AtCYP57 At4g33060	504	*	*	*	*	100	— (1)
AtCYP59 At1g53720	506	T	*	Y	*	50	— (4)
AtCYP63 At3g63400	570	*	*	H	*	75	— (4)
AtCYP65 At5g67530	595	*	*	H	*	100	— (2)
AtCYP71 At3g44600	631	*	*	*	*	100	— (3)
AtCYP95 At4g32420	837	*	S	Q	N	25	— (2)
CMH263C	238	*	*	P	*	75	S (2): 22
CMO300C	168	*	*	*	*	100	— (2)
CMP271C	310	Y	A	E	N	0	C (5): 47
CMR272C	251	*	*	Q	*	75	C (5): 78
NP_385689_S_meliloti	190	*	*	F	Y	50	S (1): 23
NP_385690_S_meliloti	169	*	*	*	Y	75	— (2)
sll0227 Syn 6803	246	*	*	G	Y	50	S (2): 28
sll0408 Syn 6803	403	*	*	N	Y	50	— (2)
slr1251 Syn 6803	170	*	*	*	*	100	— (2)

^aIsoformspresumedtobeinactiveasPPlaseareinitalics.IntracellulartargetingpredictedbyTargetPisindicated(C,chloroplast; M, mitochondrion; S, secretory pathway; —,none),togetherwiththelevelofconfidence(1,highest;4,lowest)andthepredictedlengthofthetransitpeptide.*,identitytoPPIA_HUMAN.