Table 1.

Summary of methylated Lys histone marks and corresponding KDMs/KMTs

Histone Marks	KDMs	KMTs	Target Gene Effect	General Biological Effects
H3K4Me2	KDM1A/LSD1 KDM1B/LSD2	SETD1A SET7	Activation	• Enriched over transcription binding regions of promotersa
H3K4Me3	KDM2B/FBXL10/JHDM1B KDM5A/JARID1A KDM5B/JARID1B KDM5C/JARID1C KDM5D/JARID1D	SETD1A SET7	Activation	• Enriched at the transcription start sites (TSS).b • Functions as the focal point for assembly of transcription preinitiation complex.c • Broad H3K4Me3 peak spans the enhancer regions of tumor suppressors.d
H3K9Me1	KDM1A/LSD1 KDM3A/JMJD1/JHDM2A KDM7A/JHDM1D KDM7B/PHF8	SUVR5 SUV39H1 SUV39H2	Repression	• Establishes constitutive heterochromatin.e • Regulates rRNA synthesis.f
H3K9Me2	KDM4A/JMJD2A/JHDM3A KDM4B/JMJD2B KDM4C/JMJD2C/JHDM3C KDM4D/JMJD2D KDM4E/JMJD2E	G9A SETDB1	Repression	• Establishes constitutive heterochromatin.e • Linked with endotoxin-tolerant phenotype in immune cells.g • Mediates gene silencing at subtelomeric region.h • Regulates osteogenic differentiation.i
H3K27Me3	KDM6A/UTX KDM6B/JMJD3 KDM6C/UTY KDM7A/JHDM1D	EZH1 EZH2	Repression	• Linked with silencing of inflammatory mediators.j • Enriched over senescence gene promoters.k
H3K36Me2	KDM2A/FBXL11/JHDM1A KDM2B/FBXL10/JHDM1B	SET2	Activation/Repression	• Determines rDNA promoter regulation.l
H3K36Me3	KDM4A/JMJD2A/JHDM3A KDM4B/JMJD2B KDM4C/JMJD2C/JHDM3C KDM8/JMJD5	SET2	Repression	• Associated with silencing subtelomeric transcripts.m • Regulates longevity through suppressing intragenic cryptic transcription.n
H3K56Me3	KDM4E/JMJD2E	SUV39H	Repression	• Associated with pericentromeric heterochromatin.o
H4K20Me1/2	KDM1A/LSD1 KDM7B/PHF8	SET8 SUV420H1		• Broadly distributed across genome.p • Involved in cell cycle regulation and DNA repair.p • Regulates chromatin structure during cell cycle progression.p
H4K20Me3	KDM7C/PHF2	SMYD5 SUV420H2	Repression	• Enriched at pericentric and subtelomeric heterochromatin.q
				• Regulates the expression of TLR4-target inflammatory genes.r

^aWang et al (2014);

^bLloret-Llinares et al (2012);

^cLauberth et al (2013);

^dChen et al (2015);

^eAudergon et al (2015);

^fZhu et al (2010);

^gEl Gazzar et al (2008);

^hArnoult et al (2012);

ⁱDeng et al (2015);

^jDe Santa et al (2009);

^kAgger et al (2009);

^lTanaka et al (2015);

^mSuzuki et al (2016);

ⁿSen et al (2015);

^oJack et al (2013);

^pJørgensen et al (2013);

^qShinchi et al (2015);

^rStender et al, 2012.