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. 2017 May 26;6(5):e143. doi: 10.1038/cti.2017.18

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Copyright © 2017 The Author(s)

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Helios expression by activated Treg and Tfr fractions is inversely associated with the percentage of conventional and follicular Th17- and Th17.1-type EM cells. The MFI of Helios in FrII Treg was inversely correlated to the percentage of EM cells within the Th17 (a: r=−0.556, P<0.001), Th17.1 (b: r=−0.505, P=0.001), Tfh17 (c: r=−0.626, P<0.001) and Tfh17.1 (d: r=−0.645, P<0.001) compartments. Inverse correlations with the Helios MFI of FrII Tfr and the percentage of EM Tfh17 (e: r=−0.570, P<0.001) and Tfh17.1 cells (f: r=−0.589, P<0.001) were also observed. Data are for n=37 individuals (n=18 CIS and n=19 HC).