Figure 7. Gene set enrichment for the TWEAK/Fn14 pathway in AD and psoriasis.

Gene set enrichment analysis of skin biopsies from healthy (n=8), AD (n=7), and psoriasis patients (n=9). GenePattern 2.0 (ref. ⁷⁴) was used to process RNA array data for gene set enrichment analysis⁷⁵ which was run with the default settings (100 iterations, weighted). A FDR P value <0.05 was considered significant. Fn14 (TNFRSF12A) and intracellular signalling and effector molecules are significantly enriched among the induced transcripts from AD (a) and psoriasis lesions (b) when compared to healthy control specimens (FDR P<0.05 in both comparisons). FDR, false discovery rate.