Table 2.

Differentially abundant serum proteins identified in longitudinal cohorts of vivax malaria patients.

Sl NO.	Protein name	Uniprot Accession ID	Gene Name	Unique peptides†	(FEB/HC)		(DEF/HC)		(CON/HC)
					Fold-change	Adjusted p-value	Fold-change	Adjusted p-value	Fold-change	Adjusted p-value
1	Apolipoprotein A-II	P02652	APOA2	8	0.41	0.047	0.47	0.073	0.64	0.244
2	Apolipoprotein A-I$*	P02647	APOA1	36	0.42	0.001	0.48	0.008	0.64	0.054
3	Heparin cofactor 2	P05546	SERPIND1	7	0.44	0.005	0.39	0.001	0.50	0.019
4	Apolipoprotein C-I	P02654	APOC1	3	0.45	0.003	0.40	0.00003	0.46	0.0002
5	Haptoglobin$*	P00738	HP	17	0.47	0.024	0.68	0.049	1.09	0.704
6	Inter-alpha-trypsin inhibitor heavy chain H2$	P19823	ITIH2	18	0.49	0.008	0.41	0.003	0.51	0.025
7	Serum paraoxonase/ arylesterase 1	P27169	PON1	5	0.64	0.074	0.54	0.007	0.69	0.122
8	Inter-alpha-trypsin inhibitor heavy chain H1	P19827	ITIH1	15	0.65	0.021	0.45	0.000	0.66	0.013
9	Conserved oligomeric Golgi complex subunit 4	Q9H9E3	COG4	8	0.66	0.148	0.55	0.018	0.85	0.360
10	Afamin	P43652	AFM	13	0.67	0.033	0.73	0.131	0.64	0.021
11	Apolipoprotein C-III	P02656	APOC3	5	0.68	0.031	0.68	0.041	0.73	0.209
12	Kininogen-1	P01042	KNG1	6	0.69	0.081	0.63	0.006	0.68	0.113
13	Fibronectin	P02751	FN1	22	0.72	0.030	0.58	0.005	0.63	0.009
14	Inter-alpha-trypsin inhibitor heavy chain H4	Q14624	ITIH4	24	0.72	0.043	0.63	0.056	0.71	0.035
15	Complement C5	P01031	C5	8	0.73	0.067	0.67	0.038	0.68	0.023
16	Complement C3	P01024	C3	89	0.74	0.159	0.66	0.032	0.79	0.171
17	Clusterin	P10909	CLU	12	0.75	0.106	0.68	0.003	0.71	0.092
18	Apolipoprotein B-100	P04114	APOB	145	0.77	0.030	0.63	0.002	0.76	0.029
19	Serum amyloid P-component	P02743	APCS	3	0.78	0.216	0.62	0.025	0.70	0.086
20	Complement C4-A	P0C0L4	C4A	7	0.85	0.104	0.73	0.014	1.10	0.703
21	Hemopexin$*	P02790	HPX	12	1.22	0.05	1.12	0.163	1.00	0.295
22	Apolipoprotein E*	P02649	APOE	11	1.24	0.05	1.16	0.045	0.87	0.715
23	Alpha-1-acid glycoprotein 1	P02763	ORM1	8	1.25	0.139	1.49	0.041	1.46	0.088
24	Biotinidase	P43251	BTD	2	1.30	0.045	1.12	0.555	1.10	0.685
25	Alpha-1-antichymotrypsin$	P01011	SERPINA3	26	1.42	0.036	1.28	0.379	1.22	0.096
26	Alpha-1-antitrypsin$	P01009	SERPINA1	40	1.47	0.115	1.51	0.004	1.50	0.164
27	Leucine-rich alpha-2-glycoprotein$	P02750	LRG1	7	1.83	0.005	1.63	0.037	1.49	0.047
28	Cell growth-regulating nucleolar protein	Q9NX58	LYAR	13	1.85	0.056	2.10	0.044	2.26	0.157
29	Serum amyloid A-1$*	P0DJI8	SAA1	6	2.49	0.008	1.60	0.023	2.15	0.018
30	Carbonic anhydrase 1	P00915	CA1	4	2.61	0.014	1.37	0.207	1.43	0.048
31	Hemoglobin subunit alpha	P69905	HBA1	7	2.63	0.006	1.49	0.025	1.33	0.032
32	Hemoglobin subunit beta	P68871	HBB	8	2.70	0.003	1.66	0.057	1.47	0.047
33	Hemoglobin subunit delta	P02042	HBD	7	3.77	0.005	1.89	0.101	1.83	0.036
34	C-reactive protein	P02741	CRP	4	3.91	0.003	6.69	0.006	2.45	0.001
35	Hemoglobin subunit zeta	P02008	HBZ	5	4.83	0.011	1.88	0.023	2.21	0.041

^#This is a partial list for some selected candidates (p < 0.05 in at least one comparison) identified in iTRAQ and 2D-DIGE-based quantitative proteomics analysis; complete lists of the identified differentially abundant proteins are provided under supplementary information (Tables S6, S7 and S8). ^†Median value for the identified unique peptides in different biological replicates is represented. ^$Differential abundances for these candidates are also identified in 2D-DIGE (details are provided in Table S6). *Differential serum abundances of these proteins are validated by ELISA (details are provided in Table S13A).