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. 2017 Jun 30;7:4476. doi: 10.1038/s41598-017-04762-x

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in gene expression caused by aortic constriction is reversed by atenolol treatment. Four weeks after Atenolol treatment of TAC or Sham operated mice, RNA-seq analysis of whole tissue from the left ventricle was performed. Similar tissue was collected the Solvent control group (n = 3 per group). (a) A heatmap depicting changes in gene expression of 1571 protein coding genes. Genes are ordered based on hierarchical clustering. Genes up- or down-regulated by TAC alone, relative to control (leftmost column; yellow box). Effects of β-blocker (2^nd leftmost column; blue box). (b) The total number of up and downregulated genes in each condition. (c) A select group of genes (32) were differentially regulated in both the TAC + Sol vs Sham + Sol and TAC + AT vs TAC + Sol conditions. (d) A heatmap depicting the Fold Change values of TAC + AT vs TAC + Sham and TAC + Sol vs Sham + Sol.