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. 2017 Jun 30;7:4405. doi: 10.1038/s41598-017-04492-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of adipose depots with aging and phenotypic observations. (A–C) Weights of sWAT (A), eWAT (B) and iBAT (C) depots normalized to body weights of wild-type and RPE animals. (D) Representative SEM micrographs of 90-week wild-type and RPE mice, exhibiting adipocyte loss and tissue fibrosis. Red arrows indicate sites of anomaly. (E) Histological staining of heart, liver and skeletal muscle showing no accumulation of lipid droplets in either control or RPE mice. (F) Graph representing the concentration of circulating leptin at both 60 and 90 weeks of age in either wild-type or RPE mice, as assessed by ELISA. (G) Example of HTX staining from 30-week-old wild-type and RPE sWAT, used to estimate average adipocyte surface area (left). Graph representing the adipocyte area of all counted cells in sWAT of 30-, 60- and 90-week old animals (right). Scale bars: D = 100 μm, E = 5000 μm, F = 100 μm. Data are represented as mean ± SEM.