Table 3.
Association of C-reactive protein with colorectal adenoma, by gender and BMI.
| Quartile of C-reactive protein (mg/L) | P trend | ||||
|---|---|---|---|---|---|
| Lowest | Second | Third | Highest | ||
| All subjects | |||||
| Cases/controls | 138/164 | 159/158 | 228/169 | 204/166 | |
| OR (95% CI)a | 1.0 (Reference) | 1.17 (0.85–1.61) | 1.58 (1.16–2.14) | 1.44 (1.05–1.96) | 0.0097 |
| OR (95% CI)b | 1.0 (Reference) | 1.12 (0.81–1.55) | 1.51 (1.11–2.06) | 1.30 (0.94–1.79) | 0.031 |
| OR (95% CI)c | 1.0 (Reference) | 1.06 (0.76–1.47) | 1.35 (0.98–1.86) | 1.12 (0.80–1.56) | 0.25 |
| Stratified by Gender* | |||||
| Men | |||||
| Cases/controls | 73/87 | 101/108 | 167/118 | 149/112 | |
| OR (95% CI)a | 1.0 (Reference) | 1.11 (0.73–1.68) | 1.70 (1.14–2.52) | 1.61 (1.08–2.40) | 0.0056 |
| OR (95% CI)b | 1.0 (Reference) | 1.04 (0.68–1.60) | 1.63 (1.09–2.43) | 1.41 (0.93–2.13) | 0.018 |
| OR (95% CI)c | 1.0 (Reference) | 0.97 (0.63–1.50) | 1.44 (0.96–2.18) | 1.22 (0.80–1.88) | 0.11 |
| Women | |||||
| Cases/controls | 65/77 | 58/50 | 61/51 | 55/54 | |
| OR (95% CI)a | 1.0 (Reference) | 1.39 (0.84–2.31) | 1.44 (0.87–2.37) | 1.22 (0.73–2.04) | 0.37 |
| OR (95% CI)b | 1.0 (Reference) | 1.17 (0.68–1.99) | 1.30 (0.77–2.20) | 0.99 (0.58–1.70) | 0.62 |
| OR (95% CI)c | 1.0 (Reference) | 1.13 (0.66–1.93) | 1.16 (0.67–2.00) | 0.83 (0.47–1.49) | 0.95 |
| Stratified by BMI** | |||||
| BMI ≥ median | |||||
| Cases/controls | 49/46 | 77/60 | 139/85 | 137/103 | |
| OR (95% CI)a | 1.0 (Reference) | 1.08 (0.63–1.85) | 1.40 (0.85–2.31) | 1.11 (0.68–1.81) | 0.69 |
| OR (95% CI)b | 1.0 (Reference) | 1.01 (0.58–1.77) | 1.34 (0.80–2.26) | 0.99 (0.59–1.66) | 0.90 |
| BMI < median | |||||
| Cases/controls | 89/118 | 82/98 | 89/84 | 67/63 | |
| OR (95% CI)a | 1.0 (Reference) | 1.14 (0.76–1.72) | 1.43 (0.94–2.16) | 1.45 (0.93–2.28) | 0.057 |
| OR (95% CI)b | 1.0 (Reference) | 1.08 (0.71–1.64) | 1.27 (0.83–1.94) | 1.22 (0.75–1.96) | 0.18 |
aAdjusted for age (40–49, 50–54, 55–59, 60–64, ≥65 years), sex (except when stratified by gender), and screening period.
bFurther adjusted for family colorectal cancer history, pack-years of smoking (never, ≤20, 21–40, >40 pack-years), alcohol drinking (never, past, <150, 150–299, ≥300 g per week), physical activity (METs-hour/day, quartile), and history of diabetes mellitus.
cFurther adjusted for body mass index (BMI) (<21.0, 21.0–22.9, 23.0–24.9, and ≥25.0 kg/m2).
*Interaction for sex was not significant (P = 0.281).
**Interaction for BMI was not significant (P = 0.794).