. 2017 Jun 30;7:4456. doi: 10.1038/s41598-017-04780-9

Table 4.

Association of C-reactive protein with colorectal adenoma by size and number.

	Quartile of C-reactive protein (mg/L)				P _trend
	Lowest	Second	Third	Highest	P _trend
Controls	164	158	169	166
Size
≥5mm
Cases	56	72	101	97
OR (95% CI)^a	1.0 (Reference)	1.26 (0.83–1.91)	1.66 (1.11–2.48)	1.64 (1.09–2.45)	0.012
OR (95% CI)^b	1.0 (Reference)	1.20 (0.78–1.84)	1.59 (1.06–2.39)	1.48 (0.98–2.25)	0.031
OR (95% CI)^c	1.0 (Reference)	1.15 (0.74–1.77)	1.47 (0.97–2.23)	1.33 (0.86–2.05)	0.14
<5mm
Cases	82	87	127	107
OR (95% CI)^a	1.0 (Reference)	1.10 (0.76–1.60)	1.52 (1.06–2.17)	1.31 (0.91–1.88)	0.074
OR (95% CI)^b	1.0 (Reference)	1.06 (0.72–1.55)	1.50 (1.04–2.15)	1.20 (0.83–1.76)	0.12
OR (95% CI)^c	1.0 (Reference)	0.99 (0.67–1.45)	1.32 (0.91–1.92)	1.02 (0.69–1.50)	0.53
Number
≥2
Cases	43	75	98	98
OR (95% CI)^a	1.0 (Reference)	1.65 (1.06–2.57)	2.02 (1.31–2.09)	2.04 (1.33–3.14)	0.0013
OR (95% CI)^b	1.0 (Reference)	1.58 (1.00–2.48)	1.93 (1.25–3.00)	1.84 (1.18–2.87)	0.0032
OR (95% CI)^c	1.0 (Reference)	1.49 (0.94–2.35)	1.71 (1.09–2.68)	1.53 (0.96–2.43)	0.048
1
Cases	95	84	130	106
OR (95% CI)^a	1.0 (Reference)	0.96 (0.66–1.38)	1.43 (1.01–2.03)	1.18 (0.82–1.68)	0.16
OR (95% CI)^b	1.0 (Reference)	0.91 (0.63–1.33)	1.37 (0.96–1.96)	1.08 (0.74–1.56)	0.27
OR (95% CI)^c	1.0 (Reference)	0.86 (0.59–1.27)	1.26 (0.87–1.81)	0.96 (0.65–1.40)	0.68

^aAdjusted for age (40–49, 50–54, 55–59, 60–64, ≥65 years), sex, and screening period.

^bFurther adjusted for family colorectal cancer history, pack-years of smoking (never,≤20, 21–40, >40 pack-years), alcohol drinking (never, past, <150, 150–299, ≥300 g per week), physical activity (METs-hour/day, quartile), and history of diabetes mellitus.

^cFurther adjusted for body mass index (BMI) (<21.0, 21.0–22.9, 23.0–24.9, and ≥25.0 kg/m²).